STUDI PENGARUH HIPERTIROIDISME TERHADAP SIKLUS ESTRUS DAN GAMBARAN HISTOLOGI OVARIUM PADA TIKUS BETINA (Rattus norvegicus)

Authors

  • Shinta Dwi Riestanti Brawijaya University
  • Agung Pramana W.M
  • Aris Soewondo

Abstract

Hipertiroidisme merupakan salah satu penyakit yang disebabkan oleh jumlah hormon tiroid yang disekresikan oleh kelenjar tiroid terlalu tinggi. Hipertiroidisme banyak terjadi pada wanita sebab selama proses kehamilan, janin yang sedang berkembang membutuhkan asupan yodium (iodin) yang lebih. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh induksi Natrium iodin sebagai penyebab Hipertiroidisme pada siklus estrus tikus betina (Rattus norvegicus) beserta gambaran histologi ovarium tikus betina (Rattus norvegicus). Metode yang dilakukan yaitu dengan melakukan induksi secara berlebih Natrium Iodin (NaI) yang menyebabkan Hipertirodisme kemudian dilakukan pengamatan siklus estrus dan pengamatan secara histologis melalui gambaran histologi ovarium. Hasil penelitian menunjukkan bahwa pengaruh Hipertiroidisme pada tikus betina menyebabkan siklus estrus tikus betina menjadi tidak normal dan berpengaruh terhadap fase estrus sedangkan gambaran histologis ovarium pewarnaan Hematoxylin-eosin menunjukkan tidak ada perbedaan antara tikus kontrol dengan tikus hipertiroid.

 

Kata kunci :  Hipertiroidisme, siklus estrus, ovarium.

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Published

2015-08-13

Issue

Vol. 3 No. 3 (2015)

Section

Articles

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