Potensi Fraksi Etanol Benalu Mangga (Dendrophthoe pentandra) sebagai Agen Anti Kanker Kolon pada Mencit (Mus musculus Balb/c) setelah Induksi Dextran Sulvat (DSS) danAzoxymethane (AOM)
Abstract
ABSTRAK
Penelitian ini bertujuan untuk mengetahui kemampuan Dendrophthoe pentandra dalam memperbaiki perubahan jaringan akibat kanker kolon. Fraksi etanol benalu manga diberikan pada tiga kelompok mencit dengan dosis 0,125 mg/gram BB, 0,250 mg/gram BB dan 0,500 mg/gram BB yang sudah diinduksi kanker kolon dengan 10 mg/kg AOM dan 5 % DSS dan setelah 11 minggu organ kolon diisolasi dan dibuat preparat jaringan dengan metode parafin H&E. Parameter yang diamati meliputi jumlah sel goblet dan abnormalitas struktur jaringan (dysplasia). Data diuji secara statistik menggunakan uji normalitas dan uji homogenitas.Hasil penelitian menunjukan terjadi perbaikan sel goblet pada perlakuan dosis fraksi etanol benalu mangga 0,500 mg/gram BB.Fraksi etanol benalu mangga mampu memperbaiki abnormalitas jaringan kolon yang ditunjukkan dengan tidak terjadinya dysplasia pada perlakuan fraksi etanol benalu mangga 0,250 mg/gram BB dan 0,500 mg/gram BB.Benalu mangga berpotensi sebagai agen anti kanker kolon.
.Kata kunci :AOM, benalu mangga, DSS, kanker kolon,nitrotyrosine, sel gobletReferences
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