Potential Use of Insulin Patch Technology as Transdermal Drug Delivery in Efforts to Treat Diabetes Mellitus
DOI:
https://doi.org/10.21776/ub.biotropika.2022.010.03.02Keywords:
Diabetes Mellitus, Hormone Insulin, Insulin Patch, Potential, StructureAbstract
Diabetes Mellitus (DM) in Indonesia continues to increase from 2013 to 2018. Diabetes Mellitus is associated with the production of the hormone insulin in the cells of the pancreas. An increase in blood sugar levels can stimulate insulin secretion. There are several ways to treat Diabetes Mellitus, namely by using drugs, herbal methods, and insulin injections. In addition, one of the DM treatments that can reduce pain is using insulin patch technology as a transdermal treatment. The manuscript for this publication was made to find out the potential of using insulin patch technology as transdermal drug delivery to treat DM. Using a literature review research method that discusses four focus studies, including 1) the structure of the pancreas gland, 2) the mechanism of insulin hormone production by the pancreas gland, 3) the causes, symptoms, and conditions of patients with DM, and 4) insulin patch technology as a transdermal drug in the treatment of diabetes. DM treatment efforts. In the Langerhans section of the pancreas, some cells function to produce the hormone insulin. The amino acids that make up insulin are encoded by exons formed in insulin cells. Some causes of DM namely genetics, age, the influence of food, lack of physical activity, and an unhealthy lifestyle. Some of the symptoms, namely polyuria, polydipsia, polyphagia, etc. Patients with DM need insulin intake to help balance blood sugar levels, one of which is by using an insulin patch in which there is a microneedle containing insulin n-vinylpyrrolidone (NVP) and the enzyme glucose oxidase. After a literature review, it can be concluded that the insulin patch has excellent potential and promise because during the study tested on rats and pigs obtained good results and was able to lower blood sugar levels, although development is still needed. The manuscript of this publication still has shortcomings, so the author suggested to the next author to be able to multiply the latest sources related to insulin patch. Through the creation of the publication, the manuscript realized that diabetes mellitus is a form of human negligence in maintaining the body that God has designed carefully and regularly.
References
Kementrian Kesehatan Republik Indonesia. (2020). Tetap Produktif, Cegah dan Atasi Diabetes Mellitus. In pusat data dan informasi kementrian kesehatan RI.
Saputri, S. W., Pratama, A. N. W., & Holidah, D. (2016). Studi Pengobatan Diabetes Melitus Tipe 2 dengan Komplikasi Hipertensi di Instalasi Rawat Jalan RSU dr. H. Koesnadi Bondowoso. E-Jurnal Pustaka Kesehatan, 4(3), 479–483.
Haviz, M. (2013). Dua Sistem Tubuh: Reproduksi dan Endokrin. In Jurnal Saintek (Vol. 5, Issue 2, pp. 153–168).
Yuniastuti, A., Susanti, R., & Iswari, R. S. (2018). Efek Infusa Umbi Garut (Marantha arundinaceae L) Terhadap Kadar Glukosa dan Insulin Plasma Tikus yang Diinduksi Streptozotocyn. Jurnal Mipa, 41(1), 34–39.
Tests, D., & Diabetes, F. O. R. (2015). 2. Classification and diagnosis of diabetes. Diabetes Care, 38(January), S8–S16. https://doi.org/10.2337/dc15-S005
WHO Library. (2016). Global Report on Diabetes. Isbn, 978, 6–86. http://www.who.int/about/licensing/
Wijaya, I. (2015). Continuing Medical Education Tuberkulosis Paru pada Penderita Diabetes Melitus. Cdk-229, 42(6), 412–417.
Mardiana, T., Ditama, E. M., & Tuslaela, T. (2020). an Expert System for Detection of Diabetes Mellitus With Forward Chaining Method. Jurnal Riset Informatika, 2(2), 69–76. https://doi.org/10.34288/jri.v2i2.121
Statements, P. (2012). Standards of medical care in diabetes - 2012. Diabetes Care, 35(SUPPL. 1). https://doi.org/10.2337/dc12-s011
Dennedy, M. C., Rizza, R. A., & Dinneen, S. F. (2016). Classification and Diagnosis of Diabetes Mellitus. Endocrinology: Adult and Pediatric, 1–2(January), 662-671.e2. https://doi.org/10.1016/B978-0-323-18907-1.00038-X
Hardianto, D. (2021). Telaah Komprehensif Diabetes Melitus: Klasifikasi, Gejala, Diagnosis, Pencegahan, Dan Pengobatan. Jurnal Bioteknologi & Biosains Indonesia (JBBI), 7(2), 304–317. https://doi.org/10.29122/jbbi.v7i2.4209
Rahmasari. (2019). Efektivitas Momordica Carantia (Pare) terhadap penurunan kadar glukosa darah. Jurnal Ilmiah Rekam Medis Dan Informatika Kesehatan, 9(1), 57–64.
D.W. Hestiana (2017). Journal of Health Education. Journal of Health Education, 25(1), 57–60. https://doi.org/10.1080/10556699.1994.10603001
Fu, Y., Liu, P., Chen, M., Jin, T., Wu, H., Hei, M., Wang, C., Xu, Y., Qian, X., & Zhu, W. (2022). On-demand transdermal insulin delivery system for type 1 diabetes therapy with no hypoglycemia risks. Journal of Colloid and Interface Science, 605, 582–591.
Sari, M., & Asmendri. (2020). NATURAL SCIENCE : Jurnal Penelitian Bidang IPA dan Pendidikan IPA. Natural Science: Jurnal Penelitian Bidang IPA Dan Pendidikan IPA, 6(1), 41–53. https://ejournal.uinib.ac.id/jurnal/index.php/naturalscience/article/view/1555/1159
Sulastri, A., & Husni, P. (2017). Smart Insulin Patch Inovasi Sistem Penghantar Insulin Transdermal. Farmaka, 15(November 2017), 9–17.
Hasanah, U. (2013). Insulin Sebagai Pengatur kadar Gula Darah. Jurnal Keluarga Sehat Sejahtera, 11(22), 42–49.
Brebes, B. K. (2016). Riwayat Paparan Pestisida dan Kadar Insulin Like Growth Factor I (Igf-1) pada Siswa SD Negeri Dukuhlo 01 Kecamatan Bulakamba Kabupaten Brebes. JHE (Journal of Health Education), 1(1), 26–32.
Ompusunggu, F., & Rahman, L. A. (2020). Kajian Literatur : Insulin Pump Sebagai Teknologi Sistem Monitor Glukosa Pada Diabetes Melitus. 10(1), 57–65.
Anhalt, H., & Bohannon, N. J. V. (2010). Insulin patch pumps: Their development and future in closed-loop systems. Diabetes Technology and Therapeutics, 12(SUPPL. 1). https://doi.org/10.1089/dia.2010.0016
Andriani, R., Jubir, I., Aspadiah, V., & Fristiohady, A. (2021). Review Jurnal: Pemanfaatan Etosom Sebagai Bentuk Sediaan Patch. Farmasains : Jurnal Ilmiah Ilmu Kefarmasian, 8(1), 45–57. https://doi.org/10.22236/farmasains.v8i1.5386
Adnyane, I. K. M., Winarto, A., Agungpriyono, S., Anatomi, B., Embriologi, H., Anatomi, D., & Farmakologi, F. (2012). Studi Mikroanatomi Pankreas Kodok Lembu Menggunakan Metode Pewarnaan Baku dan Immunohistokimia (Microscopal Study of Pancreas of Bullfrog Using Conventional and Immunostaining Methods). Jurnal Veteriner, 12(1), 1–6.
Gupta, R. (2017). Diabetes Treatment by Nanotechnology. Journal of Biotechnology & Biomaterials, 07(03), 4–6. https://doi.org/10.4172/2155-952x.1000268
Haviz, M. (2013). Dua Sistem Tubuh: Reproduksi dan Endokrin. In Jurnal Saintek (Vol. 5, Issue 2, pp. 153–168)
Haviz; M. (2012). 130353-ID-insulin-shock-dan-hubungannya-dengan-met.pdf. In Jurnal Sainstek: Vol. IV (Issue 2, pp. 185–191).
Suastika, K. (2018). Penuaan, Diabetes, dan Insulin. Jakarta: PT Gramedia Pustaka Utama.
Eka Banjarnahor, S. wangko. (2012). Sel Beta Pankreas. Jurnal Biomedik, 4(1), 156–162.
Yuwono, T. (2011). Biologi Molekuler (5th ed.). Jakarta, Penerbit Erlangga.
Muhammad, A. A. (2018). Resistensi Insulin Dan Disfungsi Sekresi Insulin Sebagai Faktor Penyebab Diabetes Melitus tipe 2. Jurnal Kesehatan Masyarakat, 8(2), 173–178.
Banjarnahor, E., & Wangko, S. (2012). Sel Beta Pankreas Sintesis dan Sekresi Insulin. Jurnal Biomedik, 158.
Kennedy, M. N., Bedrich, M., Huang, P., Kim, S., Bjuhr, K. K., Cross, H., Demetsky, M. (n.d.). Controlling Blood Sugar. Retrieved from University of California, San Francisco: https://dtc.ucsf.edu/types-of-diabetes/type2/understanding-type-2-diabetes/how-the-body-processes-sugar/controlling-blood-sugar/
Qaid, M. M., & Abdelrahman, M. M. (2016). Role of insulin and other related hormones in energy metabolism—A review. Cogent Food and Agriculture, 2(1). https://doi.org/10.1080/23311932.2016.1267691
Asra, Azmi. (2012). Pengaruh Konstanta Laju Transport Organ Pankreas Pada Pencapaian Konsentrasi Glukosa Darah Normal dengan Pemodelan. 3(7), 1–10.
Betteng, R. (2014). Analisis Faktor Resiko Penyebab Terjadinya Diabetes Melitus Tipe 2 Pada Wanita Usia Produktif Dipuskesmas Wawonasa. Jurnal E-Biomedik, 2(2). https://doi.org/10.35790/ebm.2.2.2014.455420
Isnaini, N., & Ratnasari, R. (2018). Faktor risiko mempengaruhi kejadian Diabetes mellitus tipe dua. Jurnal Kebidanan Dan Keperawatan Aisyiyah, 14(1), 59–68. https://doi.org/10.31101/jkk.550
Solutions, A. H. (n.d.). Type 1 DIabetes. Retrieved from Medline Plus. Trusted Health Information for You: https://medlineplus.gov/ency/article/000305.htm
Philips, K., Guppy, F., Wyszynska, G., Santos, I., & Moumen, N. (n.d.). What is Type 2 Diabetes Mellitus. Retrieved from Just Another University of Brighton Blog Network SIte: https://blogs.brighton.ac.uk/by262typ2dm/background/
Aji C, H. (2011). Gambaran Klinis dan Laboratoris Diabetes Melitus Tipe-1 pada Anak. Jurnal Kedokteran Brawijaya, 26(4), 195–198. https://doi.org/10.21776/ub.jkb.2011.026.04.2
Marzel, R. (2020). Terapi pada DM Tipe 1. Jurnal Penelitian Perawat Profesional, 3(1), 51–62. https://doi.org/10.37287/jppp.v3i1.297
Rahim, F., Deviarny, C., Yenti, R., & Ramadani, P. (2016). Formulasi Sediaan Patch Transdermal dari Rimpang Rumput Teki (Cyperus Rotundus L.) untuk Pengobatan Nyeri Sendi Pada Tikus Putih Jantan. Scientia : Jurnal Farmasi Dan Kesehatan, 6(1), 1. https://doi.org/10.36434/scientia.v6i1.34
Pujianti, E., & Airlangga, U. (2011). Optimasi Sediaan Transdermal Patch Natrium Diklofenak Tipe Matriks. Jurnal Farmasi Indonesia, 5(3), 112–119.
Hadebe, S. I., Ngubane, P. S., Serumula, M. R., & Musabayane, C. T. (2014). Transdermal delivery of insulin by amidated pectin hydrogel matrix patch in streptozotocin-induced diabetic rats: Effects on some selected metabolic parameters. PLoS ONE, 9(7). https://doi.org/10.1371/journal.pone.0101461
Arifin, A., Sartini, dan Marianti, 2019. Evaluasi Karakteristik Fisik dan Uji Permeasi pada Formula Patch Aspirin Menggunakan Kombinasi Etilselulosa dengan Polivinilpirolidon. Jurnal Sains dan Kesehatan, 2(1), 40-49.
Singh, A., & Bali, A. (2016). Formulation and characterization of transdermal patches for controlled delivery of duloxetine hydrochloride. Journal of Analytical Science and Technology, 7(1). https://doi.org/10.1186/s40543-016-0105-6
Yu, J., Wang, J., Zhang, Y., Chen, G., Mao, W., Kahkoska, A. R., Buse, J. B., Langer, R., Gu, Z., Angeles, L., Angeles, L., Angeles, L., Angeles, L., Angeles, L., Hill, C., Angeles, L., Angeles, L., Angeles, L., & Angeles, L. (2020). HHS Public Access. 4(5), 499–506. https://doi.org/10.1038/s41551-019-0508-y.Glucose-responsive
Tapan, E. (2005). Penyakit Degeneratif. Jakarta: PT Elex Media Komputindo .
Downloads
Published
Issue
Section
License
Copyright and Attribution:
Articles in Biotropika: Journal of Tropical Biology are under Creative Commons Attribution (CC-BY-SA) copyright. The work has not been published before (except in the form of an abstract or part of a published lecture or thesis) and it is not under consideration for publication elsewhere. When the manuscript is accepted for publication in this journal, the authors agree to the automatic transfer of the copyright to the publisher.
Journal of Biotropika: Journal of Tropical Biology is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Permissions:
Authors wishing to include figures, tables, or text passages that have already been published elsewhere and by other authors are required to obtain permission from the copyright owner(s) for both the print and online format and to include evidence that such permission has been granted when submitting their papers. Any material received without such evidence will be assumed to originate from one of the authors.
Ethical matters:
Experiments with animals or involving human patients must have had prior approval from the appropriate ethics committee. A statement to this effect should be provided within the text at the appropriate place. Experiments involving plants or microorganisms taken from countries other than the author's own must have had the correct authorization for this exportation.
